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It is also reported that the signaling cascades regulating Fe 2+ production were activated in RGCs isolated 24 h post RIR, which prompted the simultaneous induction of multiple genes implicated in ferroptosis and other types of RCD (97)

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In vitro models of hyperosmolarity-induced DED have indicated that treatment with ATX contributes to an increase of GPX4, promotion of iron storage, and restoration of the mitochondrial structure (125)